CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_LR594043	Streptococcus suis strain NCTC10237 chromosome 1	2 crisprs	DinG,PrimPol,csn2,cas2,cas1,cas9,csa3,cas3,DEDDh	0	0	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_LR594043_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LR594043_1

1326791-1326892

TypeII

II-A

Consensus_repeat	Method
GTTTTGAAACCATTCGAAACAGCACAGCTCTAAAAC	CRISPRCasFinder

1 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of NZ_LR594043_1

>merge|NZ_LR594043|1|1326791-1326892|CRISPRCasFinder
GTTTTGAAACCATTCGAAACAGCACAGCTCTAAAACAGAGGGTTGTTGTTAAAATCTGCCCCTATTGTTTTGAAACCATTCGAAACAGCACAGCTCTAAAAC

>NZ_LR594043|1|1|1326791-1326892|CRISPRCasFinder
GTTTTGAAACCATTCGAAACAGCACAGCTCTAAAAC	AGAGGGTTGTTGTTAAAATCTGCCCCTATT
GTTTTGAAACCATTCGAAACAGCACAGCTCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LR594043.1\|WP_014736077.1\|1335954_1338009_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|310464
NZ_LR594043.1\|WP_002935587.1\|1323794_1324151_-\|ArsC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|239332
NZ_LR594043.1\|WP_014736064.1\|1322227_1322941_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
NZ_LR594043.1\|WP_014736067.1\|1326989_1327655_-\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
NZ_LR594043.1\|WP_024405243.1\|1328851_1332994_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
NZ_LR594043.1\|WP_014736069.1\|1327985_1328852_-\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
NZ_LR594043.1\|WP_014638303.1\|1322973_1323783_-\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|236183
NZ_LR594043.1\|WP_014736074.1\|1334980_1335184_-\|holin	unknown	unknown	gnl\|CDD\|374894
NZ_LR594043.1\|WP_014736072.1\|1334140_1334851_-\|SH3-domain-containing-protein	unknown	unknown	gnl\|CDD\|377495
NZ_LR594043.1\|WP_014736060.1\|1316965_1317706_-\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738
NZ_LR594043.1\|WP_014736068.1\|1327656_1327989_-\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
NZ_LR594043.1\|WP_014736078.1\|1338021_1342464_-\|phage-tail-protein	unknown	unknown	gnl\|CDD\|377677
NZ_LR594043.1\|WP_014736075.1\|1335158_1335614_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LR594043.1\|WP_014736059.1\|1316361_1316979_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240029
NZ_LR594043.1\|WP_014736062.1\|1319071_1319650_+\|VanZ-family-protein	unknown	unknown	gnl\|CDD\|377417
NZ_LR594043.1\|WP_014736065.1\|1325690_1326365_-\|ribose-5-phosphate-isomerase-RpiA	unknown	unknown	gnl\|CDD\|234816
NZ_LR594043.1\|WP_014736061.1\|1317830_1318958_-\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NZ_LR594043.1\|WP_014736063.1\|1319784_1322052_-\|glycogen/starch/alpha-glucan-family-phosphorylase	unknown	unknown	gnl\|CDD\|340853
NZ_LR594043.1\|WP_014637063.1\|1324150_1325362_-\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_LR594043.1\|WP_014736076.1\|1335626_1335893_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_LR594043.1\|WP_014736077.1\|1335954_1338009_-\|hypothetical-protein	gnl\|CDD\|310464	pfam05895, DUF859, Siphovirus protein of unknown function (DUF859). This family consists of several uncharacterized proteins from the Siphoviruses as well as one bacterial sequence. Some of the members of this family are described as putative minor structural proteins.	0
NZ_LR594043.1\|WP_002935587.1\|1323794_1324151_-\|ArsC-family-transcriptional-regulator	gnl\|CDD\|239332	cd03034, ArsC_ArsC, Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.	1.02902e-20
NZ_LR594043.1\|WP_014736064.1\|1322227_1322941_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	5.47016e-151
NZ_LR594043.1\|WP_014736067.1\|1326989_1327655_-\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	5.38998e-106
NZ_LR594043.1\|WP_024405243.1\|1328851_1332994_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	0
NZ_LR594043.1\|WP_014736069.1\|1327985_1328852_-\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.22665e-122
NZ_LR594043.1\|WP_014638303.1\|1322973_1323783_-\|purine-nucleoside-phosphorylase	gnl\|CDD\|236183	PRK08202, PRK08202, purine nucleoside phosphorylase; Provisional.	5.58426e-162
NZ_LR594043.1\|WP_014736074.1\|1334980_1335184_-\|holin	gnl\|CDD\|374894	pfam16938, Phage_holin_Dp1, Putative phage holin Dp-1. Phage_holin_Dp1 is a family of putative phage-holins from Gram-positive bacteria, largely Firmicutes, with two probable TMSs. The family shows lytic activity.	4.9531e-12
NZ_LR594043.1\|WP_014736072.1\|1334140_1334851_-\|SH3-domain-containing-protein	gnl\|CDD\|377495	pfam05257, CHAP, CHAP domain. This domain corresponds to an amidase function. Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Escherichia coli gss, where it functions as a glutathionylspermidine amidase EC:3.5.1.78. This domain is found to be the catalytic domain of PlyCA. CHAP is the amidase domain of bifunctional Escherichia coli glutathionylspermidine synthetase/amidase, and it catalyzes the hydrolysis of Gsp (glutathionylspermidine) into glutathione and spermidine.	1.29677e-09
NZ_LR594043.1\|WP_014736060.1\|1316965_1317706_-\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	4.74208e-87
NZ_LR594043.1\|WP_014736068.1\|1327656_1327989_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.44628e-47
NZ_LR594043.1\|WP_014736078.1\|1338021_1342464_-\|phage-tail-protein	gnl\|CDD\|377677	pfam06605, Prophage_tail, Prophage endopeptidase tail. This family is of prophage tail proteins that are probably acting as endopeptidases.	1.01505e-16
NZ_LR594043.1\|WP_014736059.1\|1316361_1316979_-\|NUDIX-hydrolase	gnl\|CDD\|240029	cd04672, Nudix_Hydrolase_14, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	2.48167e-59
NZ_LR594043.1\|WP_014736062.1\|1319071_1319650_+\|VanZ-family-protein	gnl\|CDD\|377417	pfam04892, VanZ, VanZ like family. This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases.	6.57921e-06
NZ_LR594043.1\|WP_014736065.1\|1325690_1326365_-\|ribose-5-phosphate-isomerase-RpiA	gnl\|CDD\|234816	PRK00702, PRK00702, ribose-5-phosphate isomerase RpiA.	1.7394e-114
NZ_LR594043.1\|WP_014736061.1\|1317830_1318958_-\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NZ_LR594043.1\|WP_014736063.1\|1319784_1322052_-\|glycogen/starch/alpha-glucan-family-phosphorylase	gnl\|CDD\|340853	cd04300, GT35_Glycogen_Phosphorylase, glycogen phosphorylase and similar proteins. This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of oligosaccharides into glucose-1-phosphate units. They are important allosteric enzymes in carbohydrate metabolism. The allosteric control mechanisms of yeast and mammalian members of this family are different from that of bacterial members. The members of this family belong to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	0
NZ_LR594043.1\|WP_014637063.1\|1324150_1325362_-\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0

>NZ_LR594043.1|WP_014736065.1|1325690_1326365_-|ribose-5-phosphate-isomerase-RpiA
MTNLKEQVGIKAAEFVTDGMIVGLGTGSTAYYFVQEIGRRVTEEGLQITGVTTSHATAEHAASLGIPLKNIDEVEYVDLTVDGADEVDGDFNGIKGGGAALLMEKVVAVNSKDCIWIVDESKVVQTLGAFKLPVEVVQYGAENLFRLFEKKGYRPSFRMRNGEKHITDMQNFIIDLDLRRIEDTYALAEELDRTVGVVEHGLFIGLISKVIVGTPEGPNIIEKK
>NZ_LR594043.1|WP_014637063.1|1324150_1325362_-|phosphopentomutase
MPKFKRVHLVVMDSVGIGAAPDSDKFFNAGVADTESDTLGHISEKAGLEVPNMTKIGLGNIPRDTALATVPAESHPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWDGFPEEILTKIEEFSGRKIIREANKPYSGTAVIDDFGPRQMETGELIVYTSADPVLQIAAHEDIIPLDELYRICEYARSITLERPALLGRIIARPYVGEPGNFSRTANRHDYAVSPFEETVLNKLADAGVPTYSVGKISDIFNGSGITNDMGHTKSNMHGVDVLIDTLKLSDFEEGFSFTNLVDFDAVYGHRRNIEGYRDCLQEFDARIPEIIDNMREDDLLLITADHGNDPSYAGTDHTREYVPLLAYSKVFKGSGVLPVGHFADISATVAENFGVDTAMIGESFLSQLV
>NZ_LR594043.1|WP_002935587.1|1323794_1324151_-|ArsC-family-transcriptional-regulator
MEKLTVYYNPDCSKCKKLRILLPSQDMEVKWVNYLETPLRGAELTALLEKMGSQPSAVTRLKEEERLALPEEEIFERLVKEPALLNRPIIEREQTAFLCRPLEIIKEKMPEYDWSDYL
>NZ_LR594043.1|WP_014638303.1|1322973_1323783_-|purine-nucleoside-phosphorylase
MSLLAKINETKTFLEEKGLVKPEFGLILGSGLGELAQEVENAIVIDYADIPNWGKSTVVGHAGKLVYGDLAGRKVLALQGRFHFYEGNPMEVVTFPVRVMKALGCEGVIVTNAAGGIGYGPGTLMAITDHINMTGQNPLIGENLEEFGPRFPDMSNAYTKEYREKAHAIAEKLGIKLDDGVYLGVTGPTYETPAEILAFKTMGAHAVGMSTVPEVIVAAHSGMKVLGISAITNFAAGFQSELNHEEVVEVTEQIKGNFKGLVKAILAEL
>NZ_LR594043.1|WP_014736064.1|1322227_1322941_-|purine-nucleoside-phosphorylase
MSIHISAKPGEIADKILLPGDPLRAKFIAENFLEDAVCFNEVRNMFGYTGTYKGHRVSVMGTGMGMPSISIYAHELINEYGVKKLIRVGTAGSLNEDVHVRELVLAQAAATNSRMINIDWPEYDLPQIADFDLLDKAYHIAKELNMTTHVGNVLSSDSFYSPKLFSRNLELGQLGVMAVEMEAAALYYLGAKFGVQTLAIMTISDSLVNPEEDTTAEERQNTFTDMMKVGLETLIAE
>NZ_LR594043.1|WP_014736063.1|1319784_1322052_-|glycogen/starch/alpha-glucan-family-phosphorylase
MINLQNFVQSMYAKRIEDCTDQELYYALLAFTKQQSEAKYTNDQKKKVYYISAEFLIGKLLSNNLINLGLYDEVKSQLVVAGKDLIAIEDMELEPSLGNGGLGRLAACFLDSIASLGLNGDGVGLNYHFGLFRQLFEYHQQSAVPNEWITPRSWLTESPISYQVPFANFTLTSKLYDIDVPGYKMERKNRLRLFDLGSVDDNIIYDGIEFDKEDIFRNLTLFLYPDDSTDEGKVLRIFQQYFMVSNAAQLLIDEAVAKGSNLHDLPDYAVVQINDTHPSLVIPELIRLLELRGISFDEAVEIVKKMTAYTNHTILSEALEKWPLDFLNYVVPHLVPFIVELDRRAKEVKDDPAVNIIDEHGRVHMAHMDIHYGYSINGVAALHTEILKTSELKVFYELYPEKFNNKTNGITFRRWLMHVNPSLASYLDGLLGHGYHHDASELEKLLDYKNDKELKSWLEKTKQHNKRKLQRHIAKTQGVHVNPESIFDVQIKRMHEYKRQQMNVLYVIHKYLDIKAGNIPTRPLTVFFGGKAAPAYTTAQDIIHLILVLSQVIKNDPDVAPHLQLVMIENYNVTEASYIIPAADISEQISLASKEASGTGNMKFMLNGALTIGTDDGANVEIHELVGDENIYIFGQDSQTVIEHYANGTYHPYSFYEREAIRPLIDFITSDTIRHAGGIDERLWRLQDNLKHNDHFMTLLDLEDYISTKEQMLADYEDRDSWLEKVIVNIAKAGFFSSDRTIQQYDEDIWRLEVK
>NZ_LR594043.1|WP_014736062.1|1319071_1319650_+|VanZ-family-protein
MNKERFYDVINAILSFLFCRWLFMTFLFYQFSTIFMMIDFWPTLAAILLMTGFCFTLFRLVYKPHISRLTLWFFYACYGLLLVYLLFFKSMGVRGVNWDLLSTFSQDLFLNPAILVFNLLLFLPLGLLFSFSWKKLSLFVGAILLVEACQFFFSLGFFDLSDILLNTSGFVLGNLLGKSAIAQSFKNRIQKK
>NZ_LR594043.1|WP_014736061.1|1317830_1318958_-|oxygen-independent-coproporphyrinogen-III-oxidase
MKKRPTSAYIHIPFCTQICYYCDFSKVFIKNQPVDEYLATLMEEVKFYDLPALKTLYIGGGTPSALSADQLDYLLTNLEDLLDLSQVEEFTIEANPGDLTADKIAVLKKSKCNRVSLGVQTFDDRMLKKIGRSHNQAQIYETIAALKEAGFHNISIDLIYALPGQTMDQVVDNVAKALELDIPHMSLYSLILENHTVFMNRQRRGNLHLPNEDVESDMFDYILQELEKNGFEHYEISNFTKPGFESRHNLMYWDNSEYYGLGAGASGYIDGMRYRNRGPIQHYLKSIREKGHSRLHEEFLSQTEQMEEEMFLGLRKKTGVSIERFEEKFGISFEDRYGQVVRDLKNEGLLQEEDRWLRMTKKGLFLGDTVAERFI
>NZ_LR594043.1|WP_014736060.1|1316965_1317706_-|acyl-ACP-thioesterase
MGLTYQEEFTIPFDMVDVKQEIKLPDFISYCLGVSGRQSEELGRSDLYVFQEFGLIWVVTDYELTIQRLPKYNETITIKTEAVAYNKFFCHRMFYIYDAAGNLLLDILCYFVLIDFETRKVAPVPEDLIAPYQSEQVKKLPRAPKYQLLENPSVQEFPVRYFDLDMNGHVNNGKYLEWMYEALGYDFLLCHVPKKIQLKYLKEVEATSLVSSRMVVEAGVSQHEIVVDGHIHAQAVIEWRERHVAG
>NZ_LR594043.1|WP_014736059.1|1316361_1316979_-|NUDIX-hydrolase
MSQDKWLEWAVRLQALAQTGLAYGKDVYDMERFEEIRQIAAEMLVEPSGQPLEVVKDLFCNETGYQTPKLDTRAAIFQEDKILLVQENDGLWSLPGGWCDVDQSVKDNVVKEVKEEAGLDVEALRVVAILDKHKNNPAKSAHRVTKVFILCRLLGGEFQPNSETVASGFFSLDDLPPLYLGKNTADQLALCLEASRSEHWETRFD
>NZ_LR594043.1|WP_014736067.1|1326989_1327655_-|type-II-A-CRISPR-associated-protein-Csn2
MKLNFPLLDEALTVEKATIFVVEDTTVFSRLVRNLYQYQDGLELKIFDEQFRSIKDSELMVVTDILGYDINAAPILKLIHADLENQLNEKPEVKSIIEKLANSITELISYECLENELDLEYDEITVLELIKALGVKIETISDTIFDKIFEILQVYQFLNKKRFLVFINVLSYLTVDEIQKTREYIELSNMDVLFLESRKRKDFPQYVLDKDYFLLSENMVK
>NZ_LR594043.1|WP_014736068.1|1327656_1327989_-|CRISPR-associated-endonuclease-Cas2
MSYRYMRMLLMFDMPTETADERKAYRKFRKFLINEGFIMHQFSVYSKLLLNNSASNAMLERLKANNPKKGNITLLTVTEKQFARMIYLHGQRDDCIGNTDSRIVFLGEEI
>NZ_LR594043.1|WP_014736069.1|1327985_1328852_-|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTVIVNTHSKLSYKNNHLIFKDATRTEMIHLSEVDILLLETTDIVLSTMLIKRLVDENILVIFCDDKRLPTAHLMPYYARHDSSLQISKQIDWEEAVKAEVWTHIISQKILNQSIYLSACGFIEKSQSVMNLYHSLELFDPSNREGHSARIYFNTLFGNDFNRELDNDINASLDYGYTLLLSMFAREVVLSGCMTQLGLKHANQFNQFNLASDIMEPFRTIIDQIVYENRNHSFVKIKRELFTIFSDTFQYNNKEMYLTNIVSDYTKKVIKALNNNGKGVPEFRI
>NZ_LR594043.1|WP_024405243.1|1328851_1332994_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKKKYAIGIDIGTNSVGWSIVTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTAENRRLKRTARRRYTRRRNRILYLQEIFAEEINKIDDSFFQRLDDSFLIVEDKQGSKHPIFGTLQEEKEYHKQFPTIYHLRKQLADSSQKADIRLIYLALAHIIKYRGHFLFEGDLKSENKDVQHLFNDFVEMFDKTVEGSYLSENLPNVADVLVEKVSKSRRLENILHYFPNEKKNGLFGNFLALALGLQPNFKTNFELAEDAKIQFSKETYEEDLEELLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHQKDLALLKNFIHQNLSDSYKEVFNDKLKDGYAGYIEGKTTQENFYRFIKKAIEKIEGSNYFIDKIDREDFLRKQRTFDNGSIPHQIHLQEMHAIIRRQAEFYPFLVENQDKIEKILTFRIPYYVGPLARGKSEFAWLNRKSDEKIRPWNFDEMVDKETSAENFITRMTNYDRYLPDQKVLPKHSLLYEKFAVYNELTKVKFIAEGMRDYQFLDSGQKKDIVKTLFKTKRKVTAKDIKAYLENSNGYAGVELKGLEEQFNASLPTYHDLLKILRDKAFIDAEENQEILEDIVLTLTLFEDREMIRKRLEKYKDILTEEQRKKLERRHYTGWGRLSAKLINGILDKVTRKTILGYLIDDGTSNRNFMQLINDDTLSFVDEIRLAQGSGEAEDYRAEVQNLAGSPAIKKGILQSLKIVDELIEVMGYEPEHIVVEMARENQFTNQGRRNSQQRINRLENALKDFGSKILEEQKPYGVSKVNNIHLQSDRLFLYYLQNGKDMYTDEELDIDHLSEYDIDHIIPQAFIKDDSLDNKVLTKSAKNRGKSDDVPSMEIVHNRKNFWRQLLKSKLISQRKFDNLTKAERGGLTNEDKARFIQRQLVETRQITKHVARMLDTRFNTKLDEAGNRIRDPKVNIITLKSNLVSQFRKDYQLYKIREINNYHHAHDAYINAVVATALLKKYPQLAPEFVYGEYPTYNSYNSRKSATEKVLFYSNIMNFFKRIVVHSKTGEVRIRPVIEVNKETGEIVWDKKSDFRTVRKVLSYPQVNVVKKTEVQNHGLDRGKPKGFYNANLSPRPKEGSVENLVPAKQSFDTKRYGGYAGISNSYAVLVNGIIEKGKKKSKAEVTEFQGISILARKDFDKNPKQYLLNLGYKDIKSIIKLPKYSLFELENGSRRMLASILSTNNKRGEIHKGNEMYLPDKFVTLLYHAMRVNRTLEPGHKKYVETHRHVFDELLIYILEYNEKIVGAKANGKRIVEAYSARKDTDNLEELCNSFINLLNLTALGSAVDFEFLGTKIPRYRDYTPSSLLKATLIHQSVTGLYETRIDLSKLGGD
>NZ_LR594043.1|WP_014736072.1|1334140_1334851_-|SH3-domain-containing-protein
MLNQIVLYSKNLANARAGVDKDGAWGYQCADLSCFIVKKWRGVDLWGNAIDLLNSAKAQGIKVVPYAPGIKPKAGWIFVMHYVAGDGIDYGHTGVIVEDSDGNSMRTVEQNLAGNLNVGSPAQYHVRSMNGMVGFIVLADSTVSSEPTKQIETGRIAETGVFTLNSTAINVRRQPHLSGEIVATYQIGESVTYDSYLTAAGYRWISWIGRSGKRSYMAIGQVDANGHRISLWGTLK
>NZ_LR594043.1|WP_014736074.1|1334980_1335184_-|holin
MKLTNKQYDVAKTTVTIVAPAAITLISALGALYGFDATVINGTIAAVATFAGTVLGVSSKNYHQENN
>NZ_LR594043.1|WP_014736075.1|1335158_1335614_-|hypothetical-protein
MPPLLKDSAVLVALITVSGGVVGTLISTISNFFIGKRDNEVKQGQKEIIKSLDVLKNDNIKIKADLASNAEELEKLKKNSKDITRYRLYHDMTKDILNGYTTLENKREIAKLFDSYKMLDGNGEIEMMYKEEFIDLPLRKEKKDEIDKQAI
>NZ_LR594043.1|WP_014736076.1|1335626_1335893_-|hypothetical-protein
MLKVTKTRQTTAEFIVIEDKQEKLVKTTVINTGADAVSTVYETLHEPELYAKHRRDMRKHEQELRELRYKIEDEILAELDAAEVEQTE
>NZ_LR594043.1|WP_014736077.1|1335954_1338009_-|hypothetical-protein
MAKYSNASGSLYLNVYIEPGTQSIAANTTVVNWRITVSRTGAYLTYNEQGDSTLSLDLNGGRVHTSNPRWRTSGEEFLMASGSTTVGHNADGTKSFPFSATFNPNNGLHGVITVSGKISLTTIPRSSSISVEDGAIGSPIDITIERASTTFTHVLRYGWGDKKEVIASKVATSYSWTIPMDFANDIPNNVSGECTIYIDTYNGNEKIGAQQEKIKVTLPSNVKPTFTSLTLTDANTAARALLSGNNFLQIISDIQVGFNGAVGSYGSTIAGYRAEIVNRNLSTNSNGGRLGMMNFNGSATIRASVVDSRGRWSDTRDVTINVIEYFAPILSFTAQRTRQTPNIIQINRNAKIAPITLSGSQKNIMTLTFKVAPLGSTSYTADNGSASGSWTTQHTLSNSAANMAGNYPANKSFTIIGTLSDKFTSVEFSATVATESVVMSYDKDNHFAVGKIVDTNLPKGSIESTGGYYLNGKPIQNYALTSLNGASIERYNEDLNRITEPGFYIVNTSMNVPVSGRTYYYLEVIRHANNASSYVMQRATCRSHTQQTYVRICEGGTWGQWKEQVLADHPMLQEKPLKTLTMGFPYGLNATLTRKDNLVTITLNRRITNIDVFENRRMIETIPAGYRPTAQVHLVFVPNSGTITKAPSILHLNADGTIDMTNGTSGQHVYTGTISYVTNDPYPN
>NZ_LR594043.1|WP_014736078.1|1338021_1342464_-|phage-tail-protein
MLLTIHDANLKKVAFIDNDKQETLNYYDDTWTRSLETGSSTFEFTVYKKAIKSDTAINKTYNLLNERAFVSFRHNGKSYVFNVMTVEENEQTIKCYCENLNLELINEYANPYKATKAMSFVEYCNAMDLLNFTHLSVGINEISDQKRTLEWDGQDTKLARLLSLAKKFDAEIDFDTQLNADSSIKSFKVNVYHENDDKHQGVGRIRNDIQLTYGKNLKSIKRKIDKTGIYNAIRPTGKRRVKNSKGEEVEEIVTICSLDAWSENNADGVREFYQQGDFLYAPLSMQMYPSAFTSSTTNDQWIRKDMEVESDSPSVIRAAAIANLRKNAYPAITYEVDGFIDVEIGDTIKIYDNGFSPILLVQARVSDQKISFTNPNSNKTTFANFKTLENNLSDGIQAAFERLFEASKPYLIKLSTDNGVIFKNQIGQSIVTPTLYKGGKPVVAGVTWRWSLDGHTTTGMTYTVRGVDVTDTATLTIAAYIGNDEVAVDEISFVNVLDGTMGIPGTPGRDGRTPYVHTAWANNATGTSGFSLDSSINKLYIGIYTDFEPNDSTNPAKYKWTLIKGEKGEKGEKGDPGQRGLDGLQGEKGEQGIPGKNGADGRTQYTHLAYSNSADGSKDFSLSASDRSYIGMYVDFNSADSNRPSDYNWTLVKGSNGANGVAGKAGADGRTPYLHIAYSNIVLLANEFQNFNLSQTTLVRFGIEGSWVYKELSAGTYTANVATFGSDPARGKTKKVESISDFSVTDTVNKRYIGTYTDYTQEDSTDVSSYTWTLIKGDDGNGIANVTNYYLATTVSTGITKNSAGWTTTPQQISYTKRFLWNYRIELYTDGTTKTTDPTVIGVHGEKGDQGERGLQGLQGPKGDTGIQGPKGADGKSSYTHIAYATNSTGTQGFSTSDSTNKTYMGMYVDNIEADSTTPSKYHWTLIKGSDGAQGIPGAKGVDGRTPYLHIAYATNSTGTQGFSVTDSSGKTYIGQYTDFTQNDSTDPTKYKWSLIKGDKGDRGETGPQGPQGIQGIQGPKGDQGIAGAKGADGRTQYTHIAYADNATGGGFSQTDQTKAYIGMYQDFNVTDSTNPSSYRWSPWKGKDGKDGVPGPKGADGRTPYIHWAYSDSADGTGLTTSDNGQRYIGHYSDYTQADSTDKTKYRWADRWAKIEVGGQNLISGTASFSGTHWDKQGTWRLEESLYKRAGILTWVGGAKSSPIANISVQSGDTYTFSAYIKKENAGTVYFYLYDEHETWFAAANVPRETLIRDVGNNFQRFTITFKVTRSGILKPRFAIMASDTGGFSVAGYQLETGTLATDWSLAPEDIQAGIDSKADQVLTQERLNALNERAQILDAELKAKASMDALSDLEKAYQSFVKSHADSRAKAEADLAEAGRRIELLVTQFGGFKELKTFIDTYMSSSNEGLVIGKNDASSTIKVSSDRISMFSAGKEVMYISQGVIHIDNGIFTASVQIGRFRTEQYHLNVDMNVIRYVG

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Crispr_ID: NZ_LR594043_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_LR594043_2

1744144-1744242

Orphan

Consensus_repeat	Method
GGAAAGAACTCGACCATTCATAGAAGAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_LR594043_2

>merge|NZ_LR594043|2|1744144-1744242|CRISPRCasFinder
GGAAAGAACTCGACCATTCATAGAAGAGTCCGTCAACAAGTCCTAGTTTTAAGTTGTTGAGCTGGGAGTGGGAAAGAACTCGACCATCCATAGAAGAGT

>NZ_LR594043|2|2|1744144-1744242|CRISPRCasFinder
GGAAAGAACTCGACCATTCATAGAAGAGT	CCGTCAACAAGTCCTAGTTTTAAGTTGTTGAGCTGGGAGTG
GGAAAGAACTCGACCATCCATAGAAGAGT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_LR594043.1\|WP_014736365.1\|1752759_1753782_-\|ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235491
NZ_LR594043.1\|WP_009910800.1\|1750007_1750217_-\|hypothetical-protein	unknown	unknown	unknown
NZ_LR594043.1\|WP_014736361.1\|1746619_1747456_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NZ_LR594043.1\|WP_014736356.1\|1740344_1740785_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NZ_LR594043.1\|WP_014736359.1\|1743277_1744051_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_LR594043.1\|WP_014736362.1\|1747582_1749148_+\|ABC-transporter-substrate-binding-protein/permease	unknown	unknown	gnl\|CDD\|270345
NZ_LR594043.1\|WP_002942324.1\|1733687_1734686_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
NZ_LR594043.1\|WP_012775334.1\|1745769_1746492_-\|adaptor-protein-MecA	unknown	unknown	gnl\|CDD\|235030
NZ_LR594043.1\|WP_002938143.1\|1731785_1732742_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
NZ_LR594043.1\|WP_002938151.1\|1738578_1739994_-\|Fe-S-cluster-assembly-protein-SufB	unknown	unknown	gnl\|CDD\|131035
NZ_LR594043.1\|WP_002937414.1\|1750302_1751205_-\|SPFH-domain-containing-protein	unknown	unknown	gnl\|CDD\|259805
NZ_LR594043.1\|WP_014736357.1\|1740771_1741995_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_LR594043.1\|WP_002942256.1\|1753922_1754399_-\|acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
NZ_LR594043.1\|WP_014736360.1\|1744600_1745773_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NZ_LR594043.1\|WP_014736364.1\|1751214_1752465_-\|threonine-ammonia-lyase-IlvA	unknown	unknown	gnl\|CDD\|236318
NZ_LR594043.1\|WP_014736355.1\|1737064_1738306_+\|D-alanyl-D-alanine-carboxypeptidase	unknown	unknown	gnl\|CDD\|224600
NZ_LR594043.1\|WP_024405299.1\|1741998_1743261_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_LR594043.1\|WP_014736363.1\|1749140_1749884_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_LR594043.1\|WP_024405298.1\|1732743_1733688_-\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|224048
NZ_LR594043.1\|WP_014736353.1\|1735061_1736852_-\|oligopeptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173875

Protein	Function_ID	Function_description	E-value
NZ_LR594043.1\|WP_014736365.1\|1752759_1753782_-\|ketol-acid-reductoisomerase	gnl\|CDD\|235491	PRK05479, PRK05479, ketol-acid reductoisomerase; Provisional.	0
NZ_LR594043.1\|WP_014736361.1\|1746619_1747456_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	7.70313e-101
NZ_LR594043.1\|WP_014736356.1\|1740344_1740785_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	9.54023e-67
NZ_LR594043.1\|WP_014736359.1\|1743277_1744051_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	2.31431e-148
NZ_LR594043.1\|WP_014736362.1\|1747582_1749148_+\|ABC-transporter-substrate-binding-protein/permease	gnl\|CDD\|270345	cd13627, PBP2_AA_binding_like_2, Substrate-binding domain of putative amino acid-binding protein; the type 2 periplasmic-binding protein fold. This putative amino acid-binding protein belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.5711e-91
NZ_LR594043.1\|WP_002942324.1\|1733687_1734686_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.71068e-159
NZ_LR594043.1\|WP_012775334.1\|1745769_1746492_-\|adaptor-protein-MecA	gnl\|CDD\|235030	PRK02315, PRK02315, adaptor protein MecA.	2.58092e-83
NZ_LR594043.1\|WP_002938143.1\|1731785_1732742_-\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.06681e-112
NZ_LR594043.1\|WP_002938151.1\|1738578_1739994_-\|Fe-S-cluster-assembly-protein-SufB	gnl\|CDD\|131035	TIGR01980, UPF0051_protein_slr0074, FeS assembly protein SufB. This protein, SufB, forms a cytosolic complex SufBCD. This complex enhances the cysteine desulfurase of SufSE. The system, together with SufA, is believed to act in iron-sulfur cluster formation during oxidative stress. Note that SufC belongs to the family of ABC transporter ATP binding proteins, so this protein, encoded by an adjacent gene, has often been annotated as a transporter component. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_LR594043.1\|WP_002937414.1\|1750302_1751205_-\|SPFH-domain-containing-protein	gnl\|CDD\|259805	cd03407, SPFH_like_u4, Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.	2.3828e-128
NZ_LR594043.1\|WP_014736357.1\|1740771_1741995_-\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_LR594043.1\|WP_002942256.1\|1753922_1754399_-\|acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	6.83063e-74
NZ_LR594043.1\|WP_014736360.1\|1744600_1745773_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	8.76656e-81
NZ_LR594043.1\|WP_014736364.1\|1751214_1752465_-\|threonine-ammonia-lyase-IlvA	gnl\|CDD\|236318	PRK08639, PRK08639, threonine dehydratase; Validated.	0
NZ_LR594043.1\|WP_014736355.1\|1737064_1738306_+\|D-alanyl-D-alanine-carboxypeptidase	gnl\|CDD\|224600	COG1686, DacC, D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane].	1.82462e-91
NZ_LR594043.1\|WP_024405299.1\|1741998_1743261_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	5.35007e-124
NZ_LR594043.1\|WP_014736363.1\|1749140_1749884_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.51773e-147
NZ_LR594043.1\|WP_024405298.1\|1732743_1733688_-\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	9.10492e-119
NZ_LR594043.1\|WP_014736353.1\|1735061_1736852_-\|oligopeptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173875	cd08510, PBP2_Lactococcal_OppA_like, The substrate binding component of an ABC-type lactococcal OppA-like transport system contains. This family represents the substrate binding domain of an ATP-binding cassette (ABC)-type oligopeptide import system from Lactococcus lactis and other gram-positive bacteria, as well as its closet homologs from gram-negative bacteria. Oligopeptide-binding protein (OppA) from Lactococcus lactis can bind peptides of length from 4 to at least 35 residues without sequence preference. The oligopeptide import system OppABCDEF is consisting of five subunits: two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and also is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0

>NZ_LR594043.1|WP_014736359.1|1743277_1744051_-|Fe-S-cluster-assembly-ATPase-SufC
MSVLEIKDLHVEIEGKEILKGVNLTLKTGEIAAIMGPNGTGKSTLSAAIMGNPSYEVTQGEILFDGVNILELEVDERARMGLFLAMQYPSEIPGITNAEFLRAAMNAGKEDEDKISVRDFITKLDEKMELLNMKEEMAERYLNEGFSGGEKKRNEILQLLMLEPTFALLDEIDSGLDIDALKVVSKGINAMRGEGFGAMIITHYQRLLNYITPDVVHVMMEGRVVLSGGPELAQRLEKEGYVQVAAELGIDYREDDI
>NZ_LR594043.1|WP_024405299.1|1741998_1743261_-|Fe-S-cluster-assembly-protein-SufD
MTKEKIQEFSALQAEPTWLTDLRLKAFDKIAELDLPVIERVKFHRWNLGDGSLATNDEIGAVPDFTAIGDNPMLVQVGSQTVLEQLSVDLVEKGVVFTDFASAMDVIPDVLEKYLGVAVAYDEHKLAAYNTAYFNATAVLYVPDNVEIDQPVEALFYQDSTSPVAFNKRVLIIAGKNAKLNYLERFESLGDGAVATSANIVVEVIALAGSQIKFAAIDRLGKHLDTYLNRRGYLGNDATIDWAIGLLNEGNVVADLDSELKGNGSHANLKVVGLSSGRQVQGVDTRVTNYGHNSVGHILQHGVILESGTLTFNGIGHIVRGAKGADAQQESRVLMLSDKARSDANPILLIDENEVTAGHAASIGQVDPEDMYYLMSRGLDRATAERLVVRGFLGAVITEIPVKEVRDQLIAVIEEKLTKR
>NZ_LR594043.1|WP_014736357.1|1740771_1741995_-|cysteine-desulfurase
MDLERIRKDFSILDQVVNDEPLVYLDNAATTQKPQQVLDVLADYYQKDNANVHRGVHTLSERATARYEAARQKVADFIQAKSSKEILFTRGTTTSLNWVAQFAKEILQPDQEVIISVQEHHSNIIPWQQACQQTGAKLRYVTLKDGELDMDHLRSLLSSKTKFVSLAHVSNVLGSVAPIGEIAELVHQVGAYLVVDGAQSVPHMGVNVQELDVDFYAFSGHKMLGPTGIGVLYGKEELLNLMSPVEFGGEMIDFVYEQSATWKELPWKFEAGTPNIAGAIGLGAAVDYLTEIGMDAIQAHEAELVDYVFPRLQAIPGLTIYGSQDLSKRTGVIAFNLDDLHPHDVATALDYEGVAVRAGHHCAQPLLRYLQVPATVRASFYIYNTKADCDKLVEAIIKTKEFFNGPI
>NZ_LR594043.1|WP_014736356.1|1740344_1740785_-|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MALSRLDSLYMVVVSEHSKSPRHRGSLDGVEKLELHNPTCGDVIELSVKIENGKVSDIAFDGVGCTISTASASMMTEAVLGKEISQIQELAEIFSQMVQGQEDPRQKELGDASLLAGVAKFPQRIKCATLPWNALKKALERSESAD
>NZ_LR594043.1|WP_002938151.1|1738578_1739994_-|Fe-S-cluster-assembly-protein-SufB
MSEERIEPTPIDLGEYKFGFHDENVELVASTGKGLNEEVIREMSRIKGEPEWMLEFRLKSYETFKKMPMQTWGADLSELDFDDIVYYQKPSDKPARSWDDVPDKIKETFERIGIPEAERAYLAGASAQYESEVVYHNMKEEYDKHGIIFTDTDTALKEHPELFKKYFGKLVPPSDNKLAALNSAVWSGGTFIYVPKGVKLDIPLQTYFRINNEGTGQFERTLIIVDEGASVHYVEGCTAPTYSTASLHAAIVEIIAHEGAYMRYTTIQNWSDNVYNLVTKRARAEKNATVEWIDGNLGAKTTMKYPAVYLEGEGARGTMLSIAFANKGQVQDTGAKMIHNAPRTSSSIVSKSIARGGGEVNYRGQVTFAKNSAKSISHIECDTIIMDDISKSDTIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLSESEATEMIVMGFVEPFTKELPMEYAVELNRLIAYEMEGSVG
>NZ_LR594043.1|WP_014736355.1|1737064_1738306_+|D-alanyl-D-alanine-carboxypeptidase
MRKFLLTLTTVIALFFTSTPILAEDFSVAAKHAIAVEVSSGKILYEQDAETKASIASISKTLSIYLVYEALAKGEITLDTMVDISDYPYSLTSNTELSNVNLDARSYSVRDLLNASLITSSNSAIIALAEKIAGSEAAFVDRMKAKVQEWGISDAKIVNVSGLDNTDLGENIYPGSSPEDVNMFSALDVAIIARRLILDYPQVLDITSLNAYDFGSYTYYSTNQMLSDGTHARGGVDGLKTGTSNSAGSSFLATTQQAGMRIITVVLNATDGLTSPENRFVATNDLMNYVYSNFSLVTLVKKGEAFEDSKINVFNGEKETSPVVAAADLTVVQRNQTDNVPTATFTTDIKEIDAPLKAGTLVGKLQLKDQDLIGKSYISEQASVDMIIPSDMKEASWPFSWWNQFVRYVNEKL
>NZ_LR594043.1|WP_014736353.1|1735061_1736852_-|oligopeptide-ABC-transporter-substrate-binding-protein
MKKTTKLFALAGVTLLSASVLAACGSKQSGAAKQELSFPAEVKQDGTAVSDAQLKYAFVSPTTSSGLLIDELTENTTDSTFGGMVDISLFGYDGDRKLDDSGLAKAEFDVEGKKITVSLTGKDYKWSDGQPFTINDYIFTIKSMASKDYTGIRFDDKFLNIEGMQEFVDGKASDISGIKKVDDYTVELTVKEMSPSMMYAGGDVPAYIQPEHIYKDIPVADWEKSEYSRTAKLVGMGPWKIKEIVNGESITYVPNEYFFKGTKPKTSSLKIDIVSPDTIVSEMKAGNYDIADMPVDQLDSYKKASNLNIVGSLDSAYEYISFNFGKYDEAAGKNVMDENAKMNDVKLRQAIAYAIDTKTAGESLYNGLYHPAKSLIISFFGDIHDSELEGYSYNPEKAKKLLDEAGYKDVDGDGIREGKDGKAFKITFAARKRTEANEALVQQYIAWWKEVGLNVELYTGRTVEGKSFYNSVQANDAAIDMYAGGWSTGYDPNPSGLWGPIAAFNMSRFVSDENTKLLEAISSTESFDDKKNVENYKAWQKYAYEQAFAIPTFESESIVALNKRVKNYDTNYGSASGKGIALENIELTADKGVVAE
>NZ_LR594043.1|WP_002942324.1|1733687_1734686_-|ABC-transporter-ATP-binding-protein
MATEKPLLDIKDLHVGFRIGDDYFDAVDGVDISLQKNEILAIVGESGCGKSTLATTIMGLHNPLNTKITGSIQYNDMELIGMDEAKYNTVRGNDIGMIFQDPLASLNPLMTIGAQIDEALFYHTDLDANARTERVLELLAQVGIPNPKRTFKQYPHELSGGMRQRIIIAMALSCKPPIIIADEPTTALDVTIQAQILDLLNDIQAETGSGIILITHDLGVVAETADRVAVMYGGQFVEVAPVEELFTNPKHPYTRSLLKSNPQSGSEGGDLHVIEGIVPPITKMVRKGCRFAPRIPWIGAEAHEENPSMHEVGPNHFVRCTCHETFYFEGEA
>NZ_LR594043.1|WP_024405298.1|1732743_1733688_-|ATP-binding-cassette-domain-containing-protein
MVGFIEVKDFKVHYPIRSGFFNRVTDHVYAVDGVNIEFEEGKTYGLVGESGSGKSTIGKAIIGLERATSGQIIYEGQDVTNKSRGKKGNFNRDVQMIFQDSLSSFNPKKRILDIIAEPIRNFDRLSPDEEKKKVLQLLDTIGLNEEALIKYPHEFSGGQRQRIGVARALASNPRLIIADEPVSALDLSVQAQVLNYMKRIQDEFKLSYLFISHDLGVVQHMCDELFIMYRGRFVETGNKNDIYNNPQHIYTKRLLSAIPTIDPLNRLKNKEKRLAAEKEYQEMQGQYYDENGRVYDLRSFSETHQVALPEGGQN
>NZ_LR594043.1|WP_002938143.1|1731785_1732742_-|ABC-transporter-permease
MWKTVLRRLLMMIPQIIILSVIAFFVAKMMPGDPFTGLIDPNIDPAIIEQKRIAAGYYDPIPVQYFRWVGNLLQGDFGQSVIFKQPVVDVIMQRLNNTIGLSLLTMVLTYLIALPLGMIAGRYQNSLADKIIGVYNFLTFSTPTFVFAILMLWMFGFSLGWFPTRGSISGGVEGFAATLSRLHHMILPAITMAILSTTVTIQYLRTGIIDAKSQDYVRTARAKGVPERVVYNRHIFRNSILPIASFLGYELTGLIGGSIFIENIFTYPGIGQLFFNSISSRDYSVILALLLVFGMGTLLGTLISDIIMSIVDPRIRVK
>NZ_LR594043.1|WP_014736360.1|1744600_1745773_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MIPFALKYIMVIITTMVISAIATPLVRFMSLRVGAVDNPNARRINKVPMPSAGGLAIFVAFMISVLWFLPGIVTRVNYHGTYLHYIWPLVLASSIIVLTGFIDDVKELKPAPKMFGILAAATIIWIFTEFRFDSFKIPFGGPFLQFPVWLSFLLTVLWIVSITNAVNLIDGLDGLVSGVSIISLTTMGIVSYFFLHDSNIFLTLTIFVLVAAIVGFLPYNYNPAIIYLGDTGALFIGFMIGVLSLQGLKNSTAVAVVTPMIILGVPITDTVVAIIRRKLSGQKIYEADKMHLHHRLLSLGLTHRGTVLVIYTISFLFSLTSLLLNVSSRIGGILLLVTMGLGIEILCELIGIFGINRTPLLNLLRFIGNSSYRQEKIAKYKKCCEEKKRK
>NZ_LR594043.1|WP_012775334.1|1745769_1746492_-|adaptor-protein-MecA
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDLDQNLNFDEFTDLSELGDVASMTPDEFFKSLEQTVREKSAPDATAVRHLEEVEQEEEADEEEQERYIYYILEFPTIEDLFTFVGTVDYPVEESELYKMDGHYYLTVLINVENRSKQYPGYILSRMLEFTNDTKLTRPALQEHGTLMLPLAAIEELRKVPTV
>NZ_LR594043.1|WP_014736361.1|1746619_1747456_-|undecaprenyl-diphosphate-phosphatase
MLLELLKAIFLGIIEGVTEWLPVSSTGHLILVQEFVKLNQSKNFLEMFNIVIQLGAILAVMTIYFKKLNPFQPGKTKRDIQLTWQLWAKVVIACIPSILIAVPLDNWFEAHFNFMVPIAIALIVYGIAFIWIENRNSGVEPQVTDLAKMSYKTALLIGCFQVLSIVPGTSRSGATILGAIILGTSRSVAADFTFFLGIPTMFGYSGLKAVKYFLDGNSLNMEQVWILLVASVTAYLVSLVVIRFLTDFVKKHDFTVFGCYRIILGAILLVYAFITFLF
>NZ_LR594043.1|WP_014736362.1|1747582_1749148_+|ABC-transporter-substrate-binding-protein/permease
MKRKLSIFLLTLIAVFSVTTGVRADEYLRVGMEAAYAPFNWTQEDDSNGAVPIEGTNQFANGYDVQVAKKIAASMDKELLVVKTKWEGLVPALTSGKIDMIIAGMSPTEERKKEIAFSDSYYTSIPTLVVRSDSQYANATSLADFAGAKITAQQGVYLYDLIDQIEGANKQTAMGDFSQIHQALESGIIDAYVSERPEGRTAEAANKAFKMVELADSFETNAEDVTIAVGMRKDDDRIAQVNEVLATISEEEQIALMDDMIENQPVEEASEGETPSFFAQVWNIVVNNWQQLLRGTGMTLLISILGTIIGTAIGLLIGVFRTAPKAANKALAIGQKVLGWIINIYIEIFRGTPMIVQSMVIYYGTAQAFGLNLDRTLAAIFIVSINTGAYMSEIVRGGIFAVDKGQFEAATALGFTHNQTMRKIVLPQVIRNILPATGNEFVINIKDTSVLNVISVVELYFSGNTVATQTYQYFQTFTVIAIIYFILTFTVTRILRAVEKHFDTDTYTTGANQMQVEVPHD
>NZ_LR594043.1|WP_014736363.1|1749140_1749884_+|amino-acid-ABC-transporter-ATP-binding-protein
MTKNVILEIKNLKKSYGQNQVLKDISISVEKGEVISIIGSSGSGKSTFLRSINLLETPTEGQILYHGQDVLDKGYDLTTYREKLGMVFQSFNLFNNLNVLENAIVAQTTVLKRDRAEAEKIAKENLNKVGMTEQYWQAKPSQLSGGQKQRVAIARALSVDPEVILFDEPTSALDPEMVGEVLKTMQDLAKSGLTMLIVTHEMEFARDVSDRVIFMDKGVIAEEGSPQQIFENPQEERTREFLQRFLG
>NZ_LR594043.1|WP_009910800.1|1750007_1750217_-|hypothetical-protein
MTSYEKVAAVVGWVREKKITGYRISKETNAREMSVIALAQGRAKIDNISFATALGLIDFYDKNHKKFEN
>NZ_LR594043.1|WP_002937414.1|1750302_1751205_-|SPFH-domain-containing-protein
MVLGPIVFIGGFLFFVLIALILIASGLYVVKQQTVAIIERFGKYQKTSTSGINFKIPFGVDVIAARIQLRMLQSEIVVETKTQDNVFVTMNVATQYRVNENNVTDAYYKLMHPEAQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQKQVAEEMSTYGYVIVKTLITKVEPDAEVKQSMNEINAAQRKRVAAQELAEADKIKIVTAAEAEAEKDRLHGVGIAQQRKAIVDGLADSIRELKESNVSLSEEQIMSILLTNQYLDTLNNFAQGGNQTIFLPGNPEGVEDIRTQILSSLRAK
>NZ_LR594043.1|WP_014736364.1|1751214_1752465_-|threonine-ammonia-lyase-IlvA
MITAKNVEQAYSVLKRVVVRTPLDYSRYLSEKYGATIYLKRENEQRVRSFKIRGAYYAISQLTDDEKSRGVVCASAGNHAQGVAYTCQEMQIPATIFMPITTPQQKIGQVKFFGGDYVEIRLVGDTFDESAKVAQDYTQESGKTFIDPFDDENVQAGQGTVAYEILEEAEEQTISFDQILVPIGGGGLVAGVSAYLKEHAPEIKIVGVEASGARSMKAAFDKGRPVKLDQIDKFADGIAVQKVGKSTYEVARKYVDRLIGVDEGWISGTVLDLYSKLGIVAEPAGAATIATLEVVKDQIKGQTICCIISGGNNDINRMPEMEERALIYEGIKHYFVVNFPQRPGALREFVNDILGPNDDITRFEYIKRANKGTGPVLIGIALGDKTDYTQFISRLEEFDPQYINLHENDSLYKMLV
>NZ_LR594043.1|WP_014736365.1|1752759_1753782_-|ketol-acid-reductoisomerase
MAVTMQYEKDVTVAALDGKRIAVIGYGSQGHAHAQNLRDTGHDVIIGVRAGKSFDKAKEDGFETFEVAEAAKQADVIMILAPDEIQADLYNDEIAPNLEAGNALGFAHGFNVHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKHIAMDWAKGVGSARVGLLETTFKEETEEDLFGEQAVLCGGLTALMQAGFEVLTEAGYAPELAYFEVLHEMKLIVDLVYEGGFKKMRQSISNTAEFGDYVSGPRVITDQVKENMKAVLADIQSGKFANDFVNDYKAGRPRMEAYRKEAENLEIEKVGAELRKAMPFVGRNDDDAFKIYN
>NZ_LR594043.1|WP_002942256.1|1753922_1754399_-|acetolactate-synthase-small-subunit
MRRMLTAKLRNSSGVLNRFTGVLSRRQINIESISVGPTEVDGISRVTVIVDVASHDEVEQIIKQLNRLIDVVRVRDLTDIPHLEREVILVKISAPPTKRAEILAIIQPFRANVVDVAPHSITIQMTGDGDKIDALLRVIQPYGIKNIARTGATGFSRD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

329124 : 390123

Lactococcus_phage(30.0%)

holin,tRNA,protease,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002939996.1\|329124_329589_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_014735441.1\|329745_330630_+	glycosyltransferase family 2 protein	NA	NA	NA	NA
WP_014735442.1\|330738_331659_+	zinc ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014735443.1\|331692_334848_+	pneumococcal-type histidine triad protein	NA	NA	NA	NA
WP_014735444.1\|334974_335556_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
WP_014735445.1\|335748_337353_+	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	1.2e-141	46.8
WP_014735446.1\|337951_338833_+	fructose-bisphosphate aldolase	NA	NA	NA	NA
WP_001140948.1\|339225_339414_+	50S ribosomal protein L28	NA	NA	NA	NA
WP_014735448.1\|345466_347485_+	ATP-dependent DNA helicase RecG	NA	NA	NA	NA
WP_014735449.1\|347548_348508_-	asparaginase	NA	NA	NA	NA
WP_014735450.1\|348577_349423_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_014735451.1\|349424_349943_+	haloacid dehalogenase	A0A0H3UZF4	Geobacillus_virus	5.2e-19	35.5
WP_002939996.1\|350107_350572_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_004195772.1\|350714_351167_-	universal stress protein	NA	NA	NA	NA
WP_014735452.1\|351321_352536_+	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_014735453.1\|352687_353476_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_029694707.1\|353488_354019_+	cysteine hydrolase	NA	NA	NA	NA
WP_011921928.1\|354508_354856_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_012774968.1\|355041_355716_+	hydrolase	NA	NA	NA	NA
WP_011921930.1\|355932_356235_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	NA	NA	NA	NA
WP_014735455.1\|356234_357701_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	NA	NA	NA	NA
WP_014735456.1\|357700_359140_+\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	NA	NA	NA	NA
WP_073259299.1\|359458_359611_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_014735458.1\|359880_360786_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_024405250.1\|361058_363572_+	SEC10/PgrA surface exclusion domain-containing protein	NA	NA	NA	NA
WP_014735460.1\|363729_364311_+	hypothetical protein	NA	NA	NA	NA
WP_014735461.1\|364522_364630_+\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_014735462.1\|364932_365931_-	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	5.0e-10	25.2
WP_014735463.1\|366063_367227_+	galactokinase	NA	NA	NA	NA
WP_032512477.1\|367445_368927_+	UDP-glucose--hexose-1-phosphate uridylyltransferase	NA	NA	NA	NA
WP_014735466.1\|369002_369911_+	EamA family transporter	NA	NA	NA	NA
WP_014735467.1\|369958_370588_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_044752433.1\|370836_371229_+	hypothetical protein	NA	NA	NA	NA
WP_032512476.1\|371345_371885_+	YqeG family HAD IIIA-type phosphatase	NA	NA	NA	NA
WP_014735470.1\|371885_372992_+	ribosome biogenesis GTPase YqeH	NA	NA	NA	NA
WP_024405249.1\|373261_373573_+	ribosome assembly RNA-binding protein YhbY	NA	NA	NA	NA
WP_014735472.1\|373585_374218_+	nicotinate-nucleotide adenylyltransferase	G3MA22	Bacillus_virus	4.4e-20	33.8
WP_014735473.1\|374214_374802_+	HD domain-containing protein	NA	NA	NA	NA
WP_014735474.1\|374804_375260_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014735475.1\|375256_375766_+	cysteine hydrolase	NA	NA	NA	NA
WP_014735476.1\|375767_376127_+	ribosome silencing factor	NA	NA	NA	NA
WP_014735477.1\|376289_377036_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_014735478.1\|377032_378121_+	nucleotidyltransferase	NA	NA	NA	NA
WP_014735480.1\|379872_380313_+	hypothetical protein	NA	NA	NA	NA
WP_014735482.1\|382516_382927_+	peptide deformylase	A0A2I7QLT9	Vibrio_phage	9.3e-11	34.2
WP_014735483.1\|383342_385442_+\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	8.7e-121	37.3
WP_014735484.1\|387123_389388_+	glycogen/starch/alpha-glucan family phosphorylase	Q8B3H5	Iris_mild_mosaic_virus	3.2e-12	44.8
WP_002939996.1\|389658_390123_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2

DBSCAN-SWA_2

704257 : 760797

Streptococcus_phage(75.0%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_138083577.1\|704257_705514_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.1e-126	56.1
WP_002937233.1\|705657_706131_-	arginine repressor	NA	NA	NA	NA
WP_014736002.1\|706194_707223_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_014736001.1\|707568_708273_+	glucosamine-6-phosphate deaminase	NA	NA	NA	NA
WP_002937220.1\|708734_709082_+	hypothetical protein	NA	NA	NA	NA
WP_014736000.1\|709502_709817_+	hypothetical protein	NA	NA	NA	NA
WP_014735998.1\|710604_710952_+	hypothetical protein	NA	NA	NA	NA
WP_002937209.1\|711422_711548_+	teichoic acid D-Ala incorporation-associated protein DltX	NA	NA	NA	NA
WP_014735997.1\|711564_713100_+	D-alanine--poly(phosphoribitol) ligase subunit DltA	A0A2K9KZV5	Tupanvirus	5.7e-37	26.6
WP_014735996.1\|713096_714338_+	D-alanyl-lipoteichoic acid biosynthesis protein DltB	A0A125RNP0	Pseudomonas_phage	1.0e-20	29.3
WP_002937198.1\|714380_714620_+	D-alanine--poly(phosphoribitol) ligase subunit DltC	NA	NA	NA	NA
WP_014735995.1\|714612_715878_+	D-alanyl-lipoteichoic acid biosynthesis protein DltD	NA	NA	NA	NA
WP_014735994.1\|715966_717085_-	low temperature requirement protein A	NA	NA	NA	NA
WP_014735993.1\|717544_718507_-	glutathione S-transferase family protein	NA	NA	NA	NA
WP_014735992.1\|718645_719362_+	rRNA pseudouridine synthase	NA	NA	NA	NA
WP_014735991.1\|719375_719855_+	glutathione peroxidase	NA	NA	NA	NA
WP_014735990.1\|719873_720875_-	iron ABC transporter permease	NA	NA	NA	NA
WP_014735989.1\|720871_721897_-	iron ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	2.6e-14	27.2
WP_014735988.1\|721910_722840_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014735987.1\|722836_723637_-	ABC transporter ATP-binding protein	NA	NA	NA	NA
WP_014735986.1\|723788_725234_-	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
WP_014735985.1\|725380_726127_+	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
WP_002935353.1\|728541_729198_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	2.1e-113	99.1
WP_014735981.1\|729291_730119_+	hypothetical protein	M1PFV6	Streptococcus_phage	1.0e-133	98.5
WP_014735980.1\|730124_731396_+	toxic anion resistance protein	M1PLC8	Streptococcus_phage	3.5e-210	99.1
WP_002939996.1\|731537_732002_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_002935357.1\|732188_733055_-	YitT family protein	M1Q1P6	Streptococcus_phage	4.6e-153	99.7
WP_014735979.1\|733229_733868_+	dTMP kinase	M1PSC7	Streptococcus_phage	1.1e-114	99.5
WP_014735978.1\|733864_734749_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	8.6e-155	99.0
WP_002935361.1\|734768_735086_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.1e-54	100.0
WP_002935362.1\|735087_735951_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	2.1e-158	99.7
WP_014735977.1\|736419_737511_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.0e-205	99.2
WP_014735976.1\|737510_738068_+	GNAT family N-acetyltransferase	M1PSC3	Streptococcus_phage	7.0e-94	95.1
WP_014735975.1\|738271_739453_+	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.3e-219	99.5
WP_014735974.1\|739455_739962_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	4.4e-95	99.4
WP_014735973.1\|739945_740299_+	arsenate reductase family protein	M1PLC0	Streptococcus_phage	4.2e-60	99.1
WP_014735972.1\|740315_741215_-	cation transporter	M1Q1N9	Streptococcus_phage	1.3e-161	98.7
WP_014735971.1\|741514_742342_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	2.4e-151	99.3
WP_002935371.1\|742497_744159_+	hypothetical protein	NA	NA	NA	NA
WP_014735970.1\|744318_745707_+	amino acid permease	NA	NA	NA	NA
WP_014735968.1\|746903_747740_+	DUF975 family protein	NA	NA	NA	NA
WP_014735967.1\|747757_748633_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_171009919.1\|749992_751285_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	5.6e-219	96.5
WP_014735963.1\|751626_753345_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	0.0e+00	99.0
WP_014735962.1\|753435_754005_-	ECF transporter S component	NA	NA	NA	NA
WP_024405341.1\|753991_754540_-	phosphopantothenoylcysteine decarboxylase	A0A068EHP1	Penguinpox_virus	1.6e-21	35.6
WP_024387569.1\|754532_755228_-	phosphopantothenate--cysteine ligase	NA	NA	NA	NA
WP_014735961.1\|755731_757402_+	formate--tetrahydrofolate ligase	NA	NA	NA	NA
WP_014735960.1\|757441_758251_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_014735959.1\|758467_759784_+	FAD-containing oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	9.4e-89	40.6
WP_014735958.1\|759954_760797_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_3

804904 : 909960

109

Streptococcus_phage(73.47%)

portal,head,tRNA,transposase,capsid,integrase,tail,terminase,protease

attL 841307:841323|attR 848102:848118

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002939996.1\|804904_805369_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_014735924.1\|805608_806922_+	GTPase ObgE	NA	NA	NA	NA
WP_024405313.1\|807117_807672_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014735922.1\|807686_807851_+	hypothetical protein	NA	NA	NA	NA
WP_014735921.1\|807957_811224_+	ATP-dependent nuclease subunit B	NA	NA	NA	NA
WP_014735920.1\|811223_814877_+	helicase-exonuclease AddAB subunit AddA	G3MA40	Bacillus_virus	9.4e-22	23.4
WP_014735919.1\|814886_815531_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_014735918.1\|815673_817617_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	1.7e-123	42.7
WP_014735917.1\|817664_818009_+	hypothetical protein	NA	NA	NA	NA
WP_014735916.1\|818057_818660_+	Fic family protein	NA	NA	NA	NA
WP_014735915.1\|818692_819196_+	DUF1232 domain-containing protein	NA	NA	NA	NA
WP_014735914.1\|819224_819785_+	GTP pyrophosphokinase	NA	NA	NA	NA
WP_014735913.1\|819808_821155_+	hypothetical protein	NA	NA	NA	NA
WP_014735912.1\|821178_823632_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	2.9e-91	32.6
WP_014735911.1\|823852_824470_+	DUF4230 domain-containing protein	NA	NA	NA	NA
WP_014735910.1\|824580_825603_+	branched-chain amino acid aminotransferase	NA	NA	NA	NA
WP_012775068.1\|825669_825903_+	DUF2969 domain-containing protein	NA	NA	NA	NA
WP_013730343.1\|826505_827711_+	30S ribosomal protein S1	NA	NA	NA	NA
WP_029694723.1\|827891_828953_-\|integrase	site-specific integrase	A0A1X9I680	Streptococcus_phage	1.9e-108	53.8
WP_024405314.1\|829091_830108_-	Abi family protein	M1PS09	Streptococcus_phage	3.6e-48	37.3
WP_024405315.1\|830293_831052_-	ImmA/IrrE family metallo-endopeptidase	A0A1S5SC78	Streptococcus_phage	8.6e-103	69.0
WP_024405316.1\|831054_831438_-	helix-turn-helix transcriptional regulator	A0A1S5SC02	Streptococcus_phage	8.3e-46	70.9
WP_153308540.1\|831729_831870_+	hypothetical protein	NA	NA	NA	NA
WP_153308541.1\|831858_832026_-	hypothetical protein	NA	NA	NA	NA
WP_024405318.1\|832421_832616_-	hypothetical protein	NA	NA	NA	NA
WP_024381154.1\|832675_832888_+	hypothetical protein	A0A1L2JYJ6	Streptococcus_phage	1.4e-23	73.9
WP_024405319.1\|832891_833089_+	hypothetical protein	NA	NA	NA	NA
WP_024405320.1\|833318_833573_-	hypothetical protein	NA	NA	NA	NA
WP_171009920.1\|833653_833815_+	hypothetical protein	NA	NA	NA	NA
WP_024405321.1\|833970_834660_-	DUF4145 domain-containing protein	Q7Y4L0	Streptococcus_phage	4.4e-82	63.6
WP_024405322.1\|834723_835449_+	phage antirepressor KilAC domain-containing protein	M1Q1T4	Streptococcus_phage	7.1e-131	97.9
WP_029694727.1\|835529_835769_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_024376894.1\|835778_835967_+	hypothetical protein	NA	NA	NA	NA
WP_024405324.1\|835968_836223_+	hypothetical protein	NA	NA	NA	NA
WP_153308542.1\|836225_836381_+	hypothetical protein	NA	NA	NA	NA
WP_024405325.1\|836373_837342_+	phage replisome organizer N-terminal domain-containing protein	Q7Y4K5	Streptococcus_phage	5.3e-57	71.1
WP_024405326.1\|837328_837520_+	hypothetical protein	A0A1S5SEM5	Streptococcus_phage	8.6e-12	54.8
WP_153308543.1\|837519_837690_+	hypothetical protein	NA	NA	NA	NA
WP_024405327.1\|837720_837963_+	DUF3310 domain-containing protein	M1PRZ1	Streptococcus_phage	1.2e-34	93.2
WP_024405328.1\|839290_839647_+	hypothetical protein	M1NRW0	Streptococcus_phage	2.5e-60	94.1
WP_024405329.1\|839639_840146_+	DUF1642 domain-containing protein	A0A1S5SCV0	Streptococcus_phage	4.5e-15	32.0
WP_002936922.1\|840135_840297_+	hypothetical protein	A0A1X9I6R8	Streptococcus_phage	1.2e-22	100.0
WP_024405330.1\|840685_841093_+	hypothetical protein	D2IZL0	Enterococcus_phage	1.3e-12	36.8
WP_024405331.1\|841085_841295_+	hypothetical protein	A0A1X9I737	Streptococcus_phage	1.8e-15	63.2
WP_024405332.1\|841291_841495_+	hypothetical protein	M1NSG7	Streptococcus_phage	7.5e-30	97.0
841307:841323	attL	NA	NA	NA	NA
WP_024405334.1\|841762_842179_+	single-stranded DNA-binding protein	A0A1P8VVS8	Streptococcus_phage	1.3e-57	80.6
WP_024405335.1\|842188_842452_+	hypothetical protein	NA	NA	NA	NA
WP_024405336.1\|842444_842837_+	hypothetical protein	NA	NA	NA	NA
WP_153308544.1\|842846_842987_+	hypothetical protein	NA	NA	NA	NA
WP_024402323.1\|843160_843562_+	transcriptional regulator	C5J954	Streptococcus_phage	8.1e-60	85.7
WP_002939996.1\|843879_844344_+\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_024405254.1\|844508_845051_+\|integrase	tyrosine-type recombinase/integrase	A0A1S5SEW4	Streptococcus_phage	5.6e-48	55.0
WP_024405256.1\|845939_846329_+\|terminase	P27 family phage terminase small subunit	A0A1S5S8F2	Streptococcus_phage	1.1e-56	90.5
WP_024405257.1\|846321_848118_+\|terminase	terminase large subunit	C5J959	Streptococcus_phage	1.8e-300	86.7
848102:848118	attR	NA	NA	NA	NA
WP_024405258.1\|848140_849343_+\|portal	phage portal protein	C5J961	Streptococcus_phage	2.2e-185	78.2
WP_024405259.1\|849329_849908_+\|head,protease	HK97 family phage prohead protease	A0A1S5S9Y6	Streptococcus_phage	8.8e-92	88.5
WP_024405260.1\|849904_851083_+\|capsid	phage major capsid protein	A0A141E0N4	Streptococcus_phage	2.7e-148	75.4
WP_024405261.1\|851094_851439_+	hypothetical protein	C5J964	Streptococcus_phage	6.1e-16	62.9
WP_024405262.1\|851441_851723_+	hypothetical protein	A0A1S5S8H0	Streptococcus_phage	3.4e-33	74.2
WP_024405263.1\|851709_852009_+\|head	phage head closure protein	A0A1S5SEX5	Streptococcus_phage	7.1e-37	76.5
WP_024405264.1\|852005_852359_+	HK97 gp10 family phage protein	A0A1S5SFC4	Streptococcus_phage	5.6e-49	81.2
WP_024405265.1\|852691_853267_+\|tail	phage tail protein	C5J969	Streptococcus_phage	3.0e-84	80.3
WP_024390630.1\|853278_853698_+	hypothetical protein	A0A1S5S8H9	Streptococcus_phage	8.2e-55	75.5
WP_024405266.1\|854005_857026_+\|tail	phage tail tape measure protein	C5J971	Streptococcus_phage	1.4e-175	69.1
WP_024405267.1\|857022_857745_+	hypothetical protein	A0A1S5S9H2	Streptococcus_phage	1.2e-109	78.8
WP_074404474.1\|857745_860025_+\|tail	phage tail protein	A0A1P8VVT1	Streptococcus_phage	3.1e-172	77.7
WP_024405268.1\|862290_862500_+	hypothetical protein	A1EAB3	Streptococcus_phage	7.0e-23	89.9
WP_024405269.1\|862502_862847_+	hypothetical protein	M1PFF1	Streptococcus_phage	1.6e-61	99.1
WP_024405271.1\|863492_864332_+	N-acetylmuramoyl-L-alanine amidase	M1PRV7	Streptococcus_phage	9.0e-162	96.4
WP_024405272.1\|864698_864890_+	hypothetical protein	A3F673	Streptococcus_phage	1.3e-15	66.7
WP_014735909.1\|865118_866147_+	aminotransferase class V-fold PLP-dependent enzyme	NA	NA	NA	NA
WP_014735908.1\|866165_866549_-	hypothetical protein	NA	NA	NA	NA
WP_014735907.1\|866609_866996_-	hypothetical protein	NA	NA	NA	NA
WP_014735906.1\|867108_868251_+	cysteine desulfurase	NA	NA	NA	NA
WP_014735905.1\|868252_869470_+\|tRNA	tRNA 4-thiouridine(8) synthase ThiI	NA	NA	NA	NA
WP_014735904.1\|869591_870917_+	branched-chain amino acid transport system II carrier protein	NA	NA	NA	NA
WP_014735903.1\|871109_871424_+	50S ribosomal protein L21	NA	NA	NA	NA
WP_009909754.1\|871470_871764_+	50S ribosomal protein L27	NA	NA	NA	NA
WP_014735902.1\|871955_872105_+	hypothetical protein	NA	NA	NA	NA
WP_014735901.1\|872176_873091_+	LysR family transcriptional regulator	A0A2P0ZL89	Lactobacillus_phage	8.1e-07	29.5
WP_012775073.1\|873083_873548_+	signal peptidase II	NA	NA	NA	NA
WP_014735900.1\|873531_874425_+	RluA family pseudouridine synthase	NA	NA	NA	NA
WP_012775074.1\|874505_874844_+	alkylphosphonate utilization protein	NA	NA	NA	NA
WP_014735899.1\|874891_875539_+	Pr6Pr family membrane protein	NA	NA	NA	NA
WP_014735898.1\|875737_876259_+	bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR	NA	NA	NA	NA
WP_014735897.1\|876314_877238_+	aspartate carbamoyltransferase catalytic subunit	M1HGA5	Paramecium_bursaria_Chlorella_virus	1.5e-24	30.7
WP_014735895.1\|878022_879102_+	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	5.7e-60	36.7
WP_024405273.1\|879461_882641_+	carbamoyl-phosphate synthase large subunit	NA	NA	NA	NA
WP_014735893.1\|882704_883460_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_014735892.1\|883456_884104_+	pyroglutamyl-peptidase I	NA	NA	NA	NA
WP_014735891.1\|884103_884412_+	DUF4298 domain-containing protein	NA	NA	NA	NA
WP_002940682.1\|884536_884809_+	30S ribosomal protein S16	NA	NA	NA	NA
WP_012028079.1\|884830_885073_+	KH domain-containing protein	NA	NA	NA	NA
WP_014735890.1\|885148_886885_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.1e-36	25.0
WP_014735889.1\|888702_889626_-	polysaccharide deacetylase family protein	NA	NA	NA	NA
WP_014735888.1\|889730_891017_+	homoserine dehydrogenase	NA	NA	NA	NA
WP_011922331.1\|891020_891881_+	homoserine kinase	NA	NA	NA	NA
WP_014735887.1\|892114_893020_+	UDP-N-acetylmuramate dehydrogenase	NA	NA	NA	NA
WP_014637974.1\|893165_894320_+	ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	4.0e-35	40.7
WP_002938659.1\|894303_895104_+	ABC transporter permease	Q6GZ02	Mycoplasma_phage	1.3e-11	23.5
WP_014735886.1\|895103_895874_+	ABC transporter permease	NA	NA	NA	NA
WP_014735885.1\|895873_896944_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_014735884.1\|897057_898596_+	ClC family H(+)/Cl(-) exchange transporter	NA	NA	NA	NA
WP_014735882.1\|904367_905219_-	NAD(P)H-hydrate dehydratase	NA	NA	NA	NA
WP_024405274.1\|905316_905940_+	endonuclease III	NA	NA	NA	NA
WP_014735880.1\|906226_907210_+	GMP reductase	G3MBI2	Bacillus_virus	6.2e-138	74.8
WP_014735879.1\|907279_908629_+	MATE family efflux transporter	NA	NA	NA	NA
WP_014735878.1\|908726_909245_+	ribosome maturation factor RimM	NA	NA	NA	NA
WP_002941457.1\|909234_909960_+\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA

DBSCAN-SWA_4

1270575 : 1282894

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_014636255.1\|1270575_1271253_-	tyrosine-protein kinase	A0A1X9I5D6	Streptococcus_phage	2.1e-116	96.4
WP_014736031.1\|1271262_1271952_-	capsular polysaccharide biosynthesis protein CpsC	A0A1X9I5E1	Streptococcus_phage	3.0e-110	96.1
WP_014636253.1\|1271975_1273415_-	LCP family protein	A0A1X9I5X1	Streptococcus_phage	2.9e-224	98.8
WP_012775019.1\|1273519_1274254_-	peroxide stress protein YaaA	A0A1X9I5I0	Streptococcus_phage	1.5e-120	99.5
WP_011922108.1\|1274376_1275636_+	PLP-dependent aminotransferase family protein	A0A1X9I5H2	Streptococcus_phage	1.2e-239	98.8
WP_002938910.1\|1275734_1276586_-	DegV family protein	A0A1X9I5J4	Streptococcus_phage	1.3e-152	98.6
WP_014736032.1\|1276712_1277117_+	TetR/AcrR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	1.8e-62	97.0
WP_014736033.1\|1277139_1277925_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	1.8e-132	96.6
WP_024405294.1\|1280380_1282894_-	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	0.0e+00	98.2

DBSCAN-SWA_5

1292346 : 1373734

Streptococcus_phage(88.52%)

portal,tRNA,transposase,holin,integrase,tail,terminase,capsid

attL 1333994:1334013|attR 1372307:1372326

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002939996.1\|1292346_1292811_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_024405345.1\|1293915_1297002_-	Mac family protein	NA	NA	NA	NA
WP_014736043.1\|1297163_1298669_-	pyruvate kinase	NA	NA	NA	NA
WP_014736044.1\|1298735_1299746_-	6-phosphofructokinase	NA	NA	NA	NA
WP_014736045.1\|1299830_1302941_-	DNA polymerase III subunit alpha	A0A1C9LWZ5	Streptomyces_phage	1.5e-116	28.7
WP_014638280.1\|1303094_1303469_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_014736046.1\|1303461_1304169_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.7e-18	26.1
WP_014736047.1\|1304185_1304968_+	hypothetical protein	NA	NA	NA	NA
WP_014736048.1\|1305011_1306016_-	adenosine deaminase	NA	NA	NA	NA
WP_014736049.1\|1306717_1307311_+	TVP38/TMEM64 family protein	M1Q152	Streptococcus_phage	1.1e-105	99.5
WP_002935553.1\|1309382_1309706_-	metal-sulfur cluster assembly factor	NA	NA	NA	NA
WP_002935555.1\|1310052_1311171_-	RNA polymerase sigma factor RpoD	M4SMP8	Cyanophage	7.3e-34	34.1
WP_014736055.1\|1311173_1312964_-	DNA primase	A0A1S5RF71	Helicobacter_phage	6.9e-42	31.4
WP_002935562.1\|1313112_1313478_+	large conductance mechanosensitive channel protein MscL	NA	NA	NA	NA
WP_014736056.1\|1313568_1314582_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	1.4e-92	49.5
WP_000048054.1\|1314685_1314862_-	30S ribosomal protein S21	NA	NA	NA	NA
WP_014736057.1\|1314959_1315589_-	TIGR01906 family membrane protein	NA	NA	NA	NA
WP_014736058.1\|1315578_1316352_-	TIGR01457 family HAD-type hydrolase	NA	NA	NA	NA
WP_014736059.1\|1316361_1316979_-	NUDIX hydrolase	NA	NA	NA	NA
WP_014736060.1\|1316965_1317706_-	acyl-ACP thioesterase	NA	NA	NA	NA
WP_014736061.1\|1317830_1318958_-	oxygen-independent coproporphyrinogen III oxidase	NA	NA	NA	NA
WP_014736062.1\|1319071_1319650_+	VanZ family protein	NA	NA	NA	NA
WP_014736063.1\|1319784_1322052_-	glycogen/starch/alpha-glucan family phosphorylase	Q8B3H5	Iris_mild_mosaic_virus	3.7e-08	41.2
WP_014736064.1\|1322227_1322941_-	purine-nucleoside phosphorylase	NA	NA	NA	NA
WP_014638303.1\|1322973_1323783_-	purine-nucleoside phosphorylase	NA	NA	NA	NA
WP_002935587.1\|1323794_1324151_-	ArsC family transcriptional regulator	NA	NA	NA	NA
WP_014637063.1\|1324150_1325362_-	phosphopentomutase	NA	NA	NA	NA
WP_014736065.1\|1325690_1326365_-	ribose-5-phosphate isomerase RpiA	NA	NA	NA	NA
WP_014736067.1\|1326989_1327655_-	type II-A CRISPR-associated protein Csn2	NA	NA	NA	NA
WP_014736068.1\|1327656_1327989_-	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
WP_014736069.1\|1327985_1328852_-	type II CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
WP_024405243.1\|1328851_1332994_-	type II CRISPR RNA-guided endonuclease Cas9	NA	NA	NA	NA
1333994:1334013	attL	NA	NA	NA	NA
WP_014736072.1\|1334140_1334851_-	SH3 domain-containing protein	M1IFB4	Streptococcus_phage	1.6e-135	100.0
WP_014736074.1\|1334980_1335184_-\|holin	holin	M1I9T4	Streptococcus_phage	9.1e-28	100.0
WP_014736075.1\|1335158_1335614_-	hypothetical protein	M1HNU3	Streptococcus_phage	7.0e-76	100.0
WP_014736076.1\|1335626_1335893_-	hypothetical protein	M1IEU1	Streptococcus_phage	8.9e-39	100.0
WP_014736077.1\|1335954_1338009_-	hypothetical protein	M1IR90	Streptococcus_phage	0.0e+00	100.0
WP_014736078.1\|1338021_1342464_-\|tail	phage tail protein	M1IFB6	Streptococcus_phage	0.0e+00	100.0
WP_014736079.1\|1342463_1343966_-\|tail	phage tail family protein	M1I9T9	Streptococcus_phage	1.2e-297	100.0
WP_050572623.1\|1343962_1347214_-	hypothetical protein	M1HNU8	Streptococcus_phage	0.0e+00	100.0
WP_014736081.1\|1347344_1347932_-	hypothetical protein	M1IEU4	Streptococcus_phage	1.4e-108	100.0
WP_024405242.1\|1347931_1348300_-	hypothetical protein	M1IR95	Streptococcus_phage	9.3e-63	100.0
WP_014736082.1\|1348322_1348781_-	hypothetical protein	M1IFB9	Streptococcus_phage	6.6e-82	100.0
WP_014736083.1\|1348784_1349192_-\|capsid	phage capsid protein	M1I9U2	Streptococcus_phage	3.8e-73	100.0
WP_014736084.1\|1349191_1349542_-\|capsid	phage capsid protein	M1HNV2	Streptococcus_phage	1.1e-57	100.0
WP_014736085.1\|1349541_1349868_-\|capsid	phage capsid protein	M1IEU8	Streptococcus_phage	2.0e-56	100.0
WP_014736086.1\|1349857_1350253_-	hypothetical protein	M1IRA0	Streptococcus_phage	2.1e-68	100.0
WP_014736087.1\|1350296_1350551_-	hypothetical protein	M1IFC3	Streptococcus_phage	2.7e-37	100.0
WP_014736088.1\|1350561_1351440_-	hypothetical protein	M1I9U6	Streptococcus_phage	8.8e-160	100.0
WP_014736089.1\|1351458_1352025_-	phage scaffolding protein	M1HNV6	Streptococcus_phage	5.6e-83	100.0
WP_014736090.1\|1352171_1353323_-\|capsid	phage capsid protein	M1IEV1	Streptococcus_phage	7.9e-217	100.0
WP_024405241.1\|1353325_1353574_-	hypothetical protein	M1IRA5	Streptococcus_phage	1.0e-41	100.0
WP_014736092.1\|1353560_1355150_-\|portal	phage portal protein	M1IFC5	Streptococcus_phage	2.0e-303	100.0
WP_014736093.1\|1355161_1356487_-\|terminase	PBSX family phage terminase large subunit	M1I9U8	Streptococcus_phage	8.4e-263	100.0
WP_014736094.1\|1356476_1356968_-\|terminase	terminase small subunit	M1HNV8	Streptococcus_phage	2.3e-72	100.0
WP_024405240.1\|1357159_1357570_-	hypothetical protein	M1IEV3	Streptococcus_phage	8.2e-68	100.0
WP_014736096.1\|1357539_1358211_-	DUF4417 domain-containing protein	M1IRA8	Streptococcus_phage	3.5e-132	100.0
WP_014736097.1\|1358279_1358660_-	hypothetical protein	M1IFC9	Streptococcus_phage	6.5e-67	100.0
WP_014736098.1\|1358660_1358897_-	hypothetical protein	M1I9V1	Streptococcus_phage	1.0e-38	100.0
WP_024405239.1\|1358889_1359075_-	hypothetical protein	M1HNW2	Streptococcus_phage	3.5e-26	100.0
WP_014736099.1\|1359061_1359478_-	hypothetical protein	M1IEV8	Streptococcus_phage	8.3e-76	100.0
WP_024405238.1\|1359474_1359705_-	hypothetical protein	M1IRB3	Streptococcus_phage	6.1e-36	100.0
WP_014736100.1\|1359697_1359928_-	hypothetical protein	M1IFD4	Streptococcus_phage	1.6e-36	100.0
WP_014736101.1\|1359928_1360231_-	DUF1372 family protein	M1I9V5	Streptococcus_phage	1.1e-50	100.0
WP_014736102.1\|1360231_1361083_-	prohibitin family protein	M1HNW6	Streptococcus_phage	1.7e-120	100.0
WP_014736104.1\|1361277_1361682_-	hypothetical protein	M1IRB7	Streptococcus_phage	5.3e-67	100.0
WP_014736105.1\|1361702_1362440_-	hypothetical protein	M1IFD8	Streptococcus_phage	5.9e-133	100.0
WP_014736106.1\|1362441_1362876_-	hypothetical protein	M1I9V9	Streptococcus_phage	6.2e-74	100.0
WP_014736107.1\|1362886_1363321_-	helix-turn-helix transcriptional regulator	M1HNW8	Streptococcus_phage	4.5e-72	100.0
WP_014736108.1\|1363923_1364457_-	single-stranded DNA-binding protein	M1IRC1	Streptococcus_phage	1.7e-73	100.0
WP_153308538.1\|1364446_1364623_-	hypothetical protein	M1IFE1	Streptococcus_phage	1.7e-25	100.0
WP_014736109.1\|1364622_1365156_-	hypothetical protein	M1I9W2	Streptococcus_phage	2.5e-93	100.0
WP_014736110.1\|1365155_1366178_-	DUF1351 domain-containing protein	M1HNX2	Streptococcus_phage	3.5e-176	100.0
WP_014736111.1\|1366181_1366874_-	ERF family protein	M1IEW6	Streptococcus_phage	1.4e-115	100.0
WP_024405236.1\|1366877_1367456_-	hypothetical protein	K4JTL7	Streptococcus_phage	8.9e-52	93.7
WP_014736114.1\|1367689_1368007_-	DNA-binding protein	M1I9W6	Streptococcus_phage	5.8e-53	100.0
WP_014736115.1\|1368049_1368328_-	hypothetical protein	M1HNX5	Streptococcus_phage	2.4e-47	100.0
WP_153308537.1\|1368320_1368476_-	hypothetical protein	M1IEX1	Streptococcus_phage	9.7e-22	100.0
WP_014736116.1\|1368570_1369071_-	hypothetical protein	M1IRD0	Streptococcus_phage	2.2e-86	100.0
WP_014736117.1\|1369081_1369273_-	hypothetical protein	M1IFE9	Streptococcus_phage	2.3e-28	100.0
WP_014736118.1\|1369581_1369929_+	helix-turn-helix transcriptional regulator	M1I9X0	Streptococcus_phage	1.1e-57	100.0
WP_014736119.1\|1369941_1370325_+	ImmA/IrrE family metallo-endopeptidase	M1HNY1	Streptococcus_phage	2.2e-67	100.0
WP_014736120.1\|1370334_1371132_+	hypothetical protein	M1IEX3	Streptococcus_phage	1.6e-152	100.0
WP_050572622.1\|1371254_1372025_+	Arm DNA-binding domain-containing protein	M1IRD4	Streptococcus_phage	4.3e-142	100.0
WP_158306579.1\|1372008_1372302_+\|integrase	tyrosine-type recombinase/integrase	A0A1P8VVR7	Streptococcus_phage	6.0e-20	46.4
WP_014736121.1\|1372360_1373734_+\|tRNA	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	NA	NA	NA	NA
1372307:1372326	attR	NA	NA	NA	NA

DBSCAN-SWA_6

1441787 : 1486324

Lactococcus_phage(23.08%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002939996.1\|1441787_1442252_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_002937303.1\|1442476_1443067_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	1.5e-54	56.7
WP_012027487.1\|1443183_1443813_-	uracil phosphoribosyltransferase	NA	NA	NA	NA
WP_014736170.1\|1443892_1445509_-	alpha-glucosidase	NA	NA	NA	NA
WP_014736171.1\|1445783_1446944_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_014736172.1\|1446947_1448039_-	cystathionine gamma-synthase	NA	NA	NA	NA
WP_014736176.1\|1448775_1449027_+	hypothetical protein	NA	NA	NA	NA
WP_014736177.1\|1449106_1449856_+\|tRNA	tRNA1(Val) (adenine(37)-N6)-methyltransferase	NA	NA	NA	NA
WP_012775271.1\|1449845_1450115_+	GIY-YIG nuclease family protein	S5MQN3	Choristoneura_occidentalis_alphabaculovirus	2.9e-05	39.5
WP_012775272.1\|1450104_1450473_+	two pore domain potassium channel family protein	NA	NA	NA	NA
WP_012028406.1\|1450484_1451096_-	NAD(P)H-dependent oxidoreductase	NA	NA	NA	NA
WP_014736178.1\|1451228_1451636_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_002939996.1\|1451873_1452338_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_012775273.1\|1452503_1453106_-	DUF1648 domain-containing protein	NA	NA	NA	NA
WP_014736179.1\|1453092_1453371_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_014736180.1\|1453515_1455060_-	DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.3e-60	36.8
WP_002936201.1\|1455492_1456086_-	YitT family protein	NA	NA	NA	NA
WP_002936200.1\|1456163_1456547_-	PH domain-containing protein	NA	NA	NA	NA
WP_012027511.1\|1459598_1460351_+	hypothetical protein	NA	NA	NA	NA
WP_012027512.1\|1460869_1461400_-	ECF transporter S component	NA	NA	NA	NA
WP_012028411.1\|1461396_1462242_-	pyridoxamine kinase	NA	NA	NA	NA
WP_012027514.1\|1462440_1463130_-	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	NA	NA	NA	NA
WP_002936700.1\|1463138_1463459_-	hypothetical protein	NA	NA	NA	NA
WP_004194850.1\|1463469_1464015_-	NUDIX hydrolase	NA	NA	NA	NA
WP_012775275.1\|1464023_1465406_-	bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU	A0A2K9L4K9	Tupanvirus	7.2e-31	37.8
WP_012027516.1\|1465581_1466052_-	ASCH domain-containing protein	NA	NA	NA	NA
WP_004194843.1\|1466048_1466330_-	hypothetical protein	NA	NA	NA	NA
WP_014736183.1\|1466341_1467040_-	3-oxoacyl-ACP reductase	NA	NA	NA	NA
WP_004194840.1\|1467032_1467269_-	DUF2829 domain-containing protein	NA	NA	NA	NA
WP_014736184.1\|1467328_1468150_-	hypothetical protein	NA	NA	NA	NA
WP_014736185.1\|1468136_1468472_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_012027521.1\|1468468_1468633_-	hypothetical protein	NA	NA	NA	NA
WP_002939996.1\|1468938_1469403_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_014736186.1\|1469577_1471587_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_012027523.1\|1471588_1472347_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	6.5e-26	35.3
WP_012027524.1\|1472442_1473435_-	sensor histidine kinase	B5LWN0	Feldmannia_species_virus	3.2e-09	27.2
WP_014736187.1\|1473427_1474111_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.4e-27	33.2
WP_012775662.1\|1474280_1475462_+	DUF2974 domain-containing protein	NA	NA	NA	NA
WP_012027527.1\|1475476_1476601_-	aminotransferase	NA	NA	NA	NA
WP_012775663.1\|1476747_1477509_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
WP_012775664.1\|1477518_1479030_-	ABC transporter permease/substrate-binding protein	NA	NA	NA	NA
WP_012775278.1\|1479029_1479761_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	2.8e-26	33.6
WP_002936751.1\|1479753_1480203_-	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_094122528.1\|1480426_1481274_-\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	4.0e-08	25.1
WP_012027531.1\|1481411_1481948_-	YtxH domain-containing protein	NA	NA	NA	NA
WP_004194811.1\|1481931_1482345_-	DUF948 domain-containing protein	NA	NA	NA	NA
WP_012027533.1\|1482355_1483159_-	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
WP_014736188.1\|1483133_1484066_-	HPr kinase/phosphorylase	NA	NA	NA	NA
WP_032512524.1\|1484279_1485224_+	mannose-6-phosphate isomerase, class I	NA	NA	NA	NA
WP_094122528.1\|1485477_1486324_+\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	4.0e-08	25.1

DBSCAN-SWA_7

1656973 : 1719287

Lactococcus_phage(27.27%)

protease,integrase,transposase

attL 1646320:1646335|attR 1715307:1715322

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1646320:1646335	attL	NA	NA	NA	NA
WP_014736299.1\|1656973_1657900_+\|integrase	site-specific integrase	A8ATM2	Listeria_phage	1.4e-75	46.8
WP_014637146.1\|1657953_1658346_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_014636119.1\|1658366_1658612_-	hypothetical protein	NA	NA	NA	NA
WP_014736300.1\|1658789_1659422_-	hypothetical protein	NA	NA	NA	NA
WP_014736301.1\|1659414_1659888_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_014736302.1\|1659951_1660725_-	acetyl-CoA carboxylase carboxyl transferase subunit alpha	NA	NA	NA	NA
WP_014736303.1\|1660721_1661588_-	acetyl-CoA carboxylase carboxyltransferase subunit beta	NA	NA	NA	NA
WP_014736304.1\|1661602_1662976_-	acetyl-CoA carboxylase biotin carboxylase subunit	NA	NA	NA	NA
WP_014736305.1\|1663001_1663424_-	3-hydroxyacyl-ACP dehydratase FabZ	NA	NA	NA	NA
WP_014736306.1\|1663420_1663897_-	acetyl-CoA carboxylase biotin carboxyl carrier protein	NA	NA	NA	NA
WP_014736307.1\|1663897_1665133_-	beta-ketoacyl-ACP synthase II	NA	NA	NA	NA
WP_014736308.1\|1665579_1666314_-	3-oxoacyl-[acyl-carrier-protein] reductase	W8CYX9	Bacillus_phage	4.5e-08	39.8
WP_014736309.1\|1666323_1667244_-	ACP S-malonyltransferase	NA	NA	NA	NA
WP_014736310.1\|1667245_1668211_-	enoyl-[acyl-carrier-protein] reductase FabK	NA	NA	NA	NA
WP_002939996.1\|1668483_1668948_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_002938891.1\|1669137_1669362_-	acyl carrier protein	NA	NA	NA	NA
WP_014736311.1\|1669421_1670399_-	ketoacyl-ACP synthase III	NA	NA	NA	NA
WP_014736312.1\|1670395_1670830_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_014736313.1\|1670910_1671702_-	enoyl-CoA hydratase	NA	NA	NA	NA
WP_014736315.1\|1672959_1674315_+	aspartate kinase	NA	NA	NA	NA
WP_014736319.1\|1675056_1676160_-	alanine racemase	NA	NA	NA	NA
WP_012027718.1\|1676152_1676512_-	holo-ACP synthase	NA	NA	NA	NA
WP_014736320.1\|1676626_1679152_-	preprotein translocase subunit SecA	NA	NA	NA	NA
WP_014736321.1\|1679467_1682548_-	transglutaminase	NA	NA	NA	NA
WP_014736322.1\|1683158_1684043_-	ROK family protein	NA	NA	NA	NA
WP_014736323.1\|1684171_1686058_-	PTS sugar transporter subunit IIBCA	NA	NA	NA	NA
WP_024405293.1\|1686265_1687720_+	sucrose-6-phosphate hydrolase	NA	NA	NA	NA
WP_002938271.1\|1687700_1688666_+	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	4.7e-21	26.9
WP_002939996.1\|1688872_1689337_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_024405337.1\|1689503_1689923_-	transcription antitermination factor NusB	NA	NA	NA	NA
WP_014736325.1\|1689912_1690305_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_002942436.1\|1690332_1690890_-	elongation factor P	NA	NA	NA	NA
WP_014736326.1\|1690953_1692015_-	aminopeptidase P family protein	A0A0P0I8D7	Acinetobacter_phage	9.1e-18	24.6
WP_014736327.1\|1692098_1692932_-	DUF4839 domain-containing protein	NA	NA	NA	NA
WP_014736328.1\|1693063_1693237_+	hypothetical protein	NA	NA	NA	NA
WP_014736329.1\|1693266_1696092_-	excinuclease ABC subunit UvrA	A0A1B1IVR3	uncultured_Mediterranean_phage	3.8e-305	55.1
WP_002939248.1\|1696631_1697576_+	magnesium transporter CorA family protein	NA	NA	NA	NA
WP_014736330.1\|1697591_1698248_+	DUF1129 domain-containing protein	NA	NA	NA	NA
WP_002939996.1\|1698386_1698851_-\|transposase	IS200/IS605 family transposase	A0A1P8BMC0	Lactococcus_phage	2.8e-16	35.2
WP_002939250.1\|1699338_1699578_-	30S ribosomal protein S18	NA	NA	NA	NA
WP_002942409.1\|1699610_1700105_-	single-stranded DNA-binding protein	A0A2H4J1H8	uncultured_Caudovirales_phage	4.5e-60	72.5
WP_002942403.1\|1700116_1700407_-	30S ribosomal protein S6	NA	NA	NA	NA
WP_014736331.1\|1700578_1701568_-	lipoate--protein ligase	NA	NA	NA	NA
WP_050572619.1\|1701736_1702891_+	hypothetical protein	NA	NA	NA	NA
WP_024388972.1\|1702930_1704691_-	dihydrolipoyl dehydrogenase	NA	NA	NA	NA
WP_014736335.1\|1704960_1706349_-	dihydrolipoamide acetyltransferase	NA	NA	NA	NA
WP_014736336.1\|1706689_1707685_-	alpha-ketoacid dehydrogenase subunit beta	NA	NA	NA	NA
WP_013730549.1\|1708095_1709064_-	thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	NA	NA	NA	NA
WP_002942388.1\|1709295_1709955_+	trimeric intracellular cation channel family protein	NA	NA	NA	NA
WP_014736337.1\|1709990_1711145_-	carbohydrate-binding domain-containing protein	NA	NA	NA	NA
WP_014736338.1\|1711313_1711985_-	hypothetical protein	NA	NA	NA	NA
WP_002942382.1\|1712266_1712620_-	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_014736339.1\|1712775_1715598_-	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	4.1e-17	23.4
1715307:1715322	attR	NA	NA	NA	NA
WP_043028741.1\|1715615_1715954_-	YlxQ-related RNA-binding protein	NA	NA	NA	NA
WP_002942375.1\|1715910_1716207_-	YlxR family protein	NA	NA	NA	NA
WP_014736340.1\|1716223_1717366_-	transcription termination/antitermination protein NusA	NA	NA	NA	NA
WP_014736341.1\|1717439_1717910_-	ribosome maturation factor RimP	NA	NA	NA	NA
WP_094122528.1\|1718440_1719287_+\|transposase	IS630 family transposase	S5VXX4	Leptospira_phage	4.0e-08	25.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_LR594043

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection